For adults of age 18 years & more, hypertension is systolic blood pressure >140 mmHg and/ or diastolic blood pressure >90 mmHg.
1. Diuretics
This group of drugs flushes excess sodium from the body, which reduces the amount of fluid in the blood and helps to lower your blood pressure. Examples Chlorothiazide, Chlorthalidone, etc.
Compelling indications:
- Heart failure
- Elderly patients
- Systolic hypertension
Compelling contraindications:
- Gout
2. Beta-blockers (BB)
Compelling indications:
- Angina
- After MI
- Tachyarrhythmia
Possible indications:
- Heart failure
- Pregnancy
Compelling contraindications:
- Uncontrolled asthma and Chronic obstructive pulmonary disease (COPD)
- Heart block ( second or third-degree atrioventricular block)
Possible contraindications:
- Athletes and physically active patients
- Peripheral vascular disease
3. Angiotensin-converting enzyme (ACE) inhibitors:
Compelling indications:
- Heart failure
- LV dysfunction
- After MI
- Diabetic nephropathy
Possible indications:
- Chronic renal parenchymal disease
Compelling contraindications:
- Pregnancy
- Hyperkalemia
- Bilateral renal artery stenosis
4. Angiotensin receptor blockers (ARB)
This group of drugs blocks angiotensin II hormone from binding with receptors in the blood vessels. When angiotensin II is blocked, the blood vessels do not constrict or narrow, which can lower your blood pressure. Examples Losartan, Telmisartan, etc.
Compelling indications:
- ACE inhibitor cough
- Heart failure
- Diabetic nephropathy
Possible indications:
- Chronic renal parenchymal disease
Compelling contraindications:
- Pregnancy
- Bilateral renal artery stenosis
- Hyperkalemia
5. Calcium channel blockers (CCB)
Compelling indications:
- Angina
- Elderly patients
- Systolic hypertension
Possible indications:
- Peripheral vascular disease
Compelling contraindications:
- Heart block ( second or third-degree atrioventricular block with verapamil or diltiazem)
Possible contraindications:
- Congestive heart failure ( Verapamil or diltiazem)
- Longo DL, Fauci AS, Kasper DL, Hauser SL, Jamenson J. Harrinson´ s manual of medicine. 2013.
- Reid J. John Murtagh's General Practice (; John Murtagh and Jill Rosenblatt). 2015.
- https://www.nhp.gov.in/disease/cardio-vascular/hypertension-high-blood-pressure