Monday, August 31, 2020

Vaginal Discharge

Introduction:

Fluid or mucus that comes from the vagina & made up of skin cells of the vagina and cervix under the influence of the female hormone, estrogen.

Vaginal discharge is called abnormal when it occurs with the following symptoms :

  • Itching of the vagina (in & around)
  • Redness, pain, or swelling around the vagina.
  • Foamy, greenish-yellow/ bloody discharge
  • Discharge with bad smells 
  • Pain during urination or sex
  • Pain in the lower abdomen
  • Fever

Causative organisms:

  • Gardnerella vaginalis
  • Mycoplasma
  • Candida albicans
  • Trichomonas vaginalis
If the discharge is:
  • Milky white or clear 
  • (oxidises to yellow or brown)
  • Thin or mucoid
  It is Physiological
  No Treatment required, Maintain hygiene 

If the discharge is:
  • Gray in color
  • Watery, profuse & bubbly
  • Malodorous with fishy odor 

                        ๐Ÿ‘‡
It is Bacterial vaginosis due to overgrowth of Gardnerella vaginalis and other anaerobes such as Mobiluncus species


๐Ÿ’ŠTreatment is:
  • Metronidazole 400 mg per oral twice a day for 5 days 
  • Clindamycin 300 mg per oral twice a day for 7 days or clindamycin 2% cream at night for 7 nights
  • Restore pH with douches (e.g. topical Acigel or vinegar, 3–4 tbsp/L water)
  • Male sexual partner usually not treated

If discharge is:
  • White in color
  • Thick (cream cheese)
  • Non-odorous


                     ๐Ÿ‘‡
It is Vaginal thrush (Candidal vaginitis)


๐Ÿ’ŠFor Treatment we can use amphotericin, clotrimazole, econazole, isoconazole, miconazole, nystatin, ketoconazole or fluconazole.
Examples are:
  • Clotrimazole 500 mg vaginal tablet stat, and/or clotrimazole 2% cream applied to vagina and vulva (for symptomatic relief) or (esp. if recurrent)
  • Nystatin pessaries, once daily for 7 days and/or Nystatin vaginal cream, 4 gm once daily for 7 days or (if reluctant)  
  • Fluconazole 150 mg per oral as a single dose or Ketoconazole 200 mg per oral twice a day for 5 days
  • Male sexual partner usually not treated (on current evidence). 
  • If the male is symptomatic, treat with Clotrimazole 1% + Hydrocortisone 1% topically, twice a day until 2 weeks after symptoms resolve
Along with treatment:
  • Wash genital area twice/thrice a day 
  • Dry the area thoroughly
  • Wear loose-fitting cotton underwear
  • Avoid wearing tight clothing or using tampons
  • Avoid vaginal douches, powders or deodorants
If discharge is:
  • Yellow/green
  • Bubbly, profuse (muco-purulent)
  • Malodorous with fishy odor



                         ๐Ÿ‘‡
It is Trichomonas vaginalis

๐Ÿ’ŠTreatment is:
  • Oral Metronidazole 2 g as a single dose (preferable) or 400 mg bd for 7 d (if relapse) or tinidazole 2 g as a single dose
  • Use Clotrimazole 2% vaginal cream daily for 3 nights during pregnancy
  • Attention to hygiene
  • The sexual partner must be treated simultaneously
  • The male partner should use condom during intercourse
  • For resistant infections a 3–7 days course of either Metronidazole or Tinidazole 
If discharge is:
  • Yellow (may be bloody)
  • Thin—slight to moderate
                ๐Ÿ‘‡
It is Atrophic vaginitis

๐Ÿ’ŠTreatment is
  • Oral hormone replacement therapy
  • Local oestrogen cream or tab (e.g. Vagifem).The tab is preferred as it is less messy

If Vaginal discharge is present along with
  • Burning while passing urine, increased frequency 
  • Genital complaints by sexual partners  
  • Low backache 
๐Ÿ’ŠTreatment is:
  • Tab. Secnidazole 2 g OD Stat + Cap. Fluconazole 150 mg OD Stat
  • Treat partners when symptomatic
  • Rule out pregnancy
If the discharge is:
  • Yellow green (from cervix)
  • Thick—mucopurulent
  • Usually malodorous
  • Associated with Burning while passing urine, increased frequency, Genital complaints by sexual partners, Low backache
            ๐Ÿ‘‡
It is Cervical discharge (Cervicitis)
Treatment is 
  • Tab. Azithromycin 1 gm OD Stat + Tab. Cefixime 400 mg OD Stat
  • Treat partners when symptomatic
  • Rule out pregnancy
References:
  1. Murtagh J, Leggat PA. John Murtagh’s General Practice Companion Handbook.
  2. Park, K. (2019). Park's textbook of preventive and social medicine. 25th. Jabalpur, India: M/S Banarsidas Bhanot.
  3. Kadri AM. (2019). IAPSM's Textbook of Community Medicine. 1st. New Delhi, India: Jaypee Brothers Medical Publishers (P) Ltd.



Seminar: Cohort study design